Activo-Darwin semi-automated peptide synthesizer is an economical instrument for the synthesis of very high quality peptides.

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Activo-Darwin semi-automated peptide synthesizer brochure

Key Features

  • High quality peptides
  • Any scale from 0.05 to 20.0 mmoles
  • Easy to use; use existing or define your own protocols
  • Automates the resin washing and deprotection steps of synthesis
  • Performs any Fmoc or t-Boc chemistries
  • Compatible with green chemistry solvents
  • Heated reactors ambient to + 90°C
  • PNA synthesis
  • Safe to use, instrument is totally enclosed
  • Disposable reactors
  • Uses commercially available resins and reagents
Sequence: GRKKRRQRRRGYKCC Scale: 0.16 mmol Synthesis: conventional room temperature Resin: Rink MBHA, 0.64 mmol/g Double coupling PyBOP/DIEA in DMF, 3 eq. amino acids and 2.8 eq. PyBOP Cleavage: 94% TFA, 2.5% EDT, 2.5% H20 and 1% TIS Crude purity 94%

High Quality Peptides

  • Inert atmosphere throughout
  • Precise and fast reagent delivery and washing
  • Efficient inversion & nitrogen bubbling mixing
  • Bottom filtration from disposable reactors

Ease of Use

  • Very easy to use touch screen display
  • Enter the sequence, fill in quantity and resin and press run
  • Software generated worksheet tells the user what to prepare
  • Free choice of chemistry, present and future
  • Disposable reactors
  • Logfile of each synthesis
  • Easy cleave system direct from the disposable reactor
  • Email notifications


  • Fmoc or t-Boc
  • In situ or pre-activation
  • Green chemistry
  • Coupling reagents HBTU, HCTU, HATU, TBTU, PyBOP, DIC, COMU etc
  • PNA synthesis
  • Use any resins; polystyrene or PEG
  • Use any protocols
  • Synthesize any length of peptides


Activo-Darwin semi-automated peptide synthesizer Specification

Scale 0.05 – 20.0 mmoles
Chemistry Fmoc or t-Boc
Activation method Pre-activation or in-situ, user selectable. HATU, HBTU, HCTU, DIC, PyBOP, etc
Reaction vessel sizes 10 mL, 40 mL, 125 mL, 250mL, 500mL
Reagent/solvent bottles 3 as standard – range from 250 mL to 19 litres, 4th optional
Reactor heating ambient to + 90°C
Mixing system Over centre mixing with variable speed and amplitude (N2 mixing optional)
Inert atmosphere 100% throughout the system
Fluid measurement Timed delivery
Power Variable range from 240V/50Hz or 100V/60Hz
Logfile Printable logfile for each synthesis run
Dimensions Width 42 cm (17”), depth 31 cm (12”), height 60 cm (24”)


Technical Support

Activotec has unsurpassed experience in the synthesis and automation processes for peptides. Activotec is totally committed to supporting its customers worldwide.

  • Fast reliable service engineers and application chemists.
  • Service contract options are available to suit your requirements.
  • Peptide chemists are available to help with instrument application and peptide chemistry if required.
  • Training is provided on site or in our facility.


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